To understand whether you can take Xarelto together with alcohol, its important to understand how the drug works. Often, its recommended for people with sour stomachs to make lifestyle changes such as avoiding caffeinated beverages and other indigestion triggers like alcohol and spicy, fatty, or high-sugar foods. The use of the Truven Health products is at your sole risk. eHealthMe is studying from 197,108 Xarelto users for its effectiveness, alternative drugs and more. Mixing alcohol with blood thinners can increase the risk of bleeding and should be avoided in most cases. If you notice any other effects, check with your healthcare professional. Frequently asked questions regarding Xarelto and alcohol. recommends taking this medication (or any PPI) at the lowest effective dose for the shortest possible time. Grapefruit juice can interfere with many medications, including certain beta blockers, by reducing the medications absorption, says Dr. Helzer. There are certain medications that can change the amount of Xarelto (rivaroxaban) in your body. topiramate to maximize effects in people looking to lose weight. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.AmiodaroneCyclosporineDiltiazemDronedaroneErythromycinVerapamil. Coffee Affection is reader-supported. Xarelto and alcohol: can they be used together? - NiceRx Side effects include back pain, itchy skin, abdominal discomfort, and bleeding. If you have CAD or PAD, Xarelto (rivaroxaban) should be taken together with low-dose aspirin (75 mg to 100 mg) to lower your risk of serious heart-related problems. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. And if you are on beta blockers due to a tachyarrhythmia (abnormal heart rhythm marked by a ventricular rate of 100+ beats per minute) such as atrial fibrillation, palpitations, etc., you should limit your caffeine intakethats not so much because of the beta blocker, but due to the underlying condition, adds Carlos Ince, MD, a board-certified cardiologist at The Heart Center at Mercy in Baltimore, Maryland. However, both Xarelto and alcohol act as blood thinners, and it can be dangerous to combine a drug and a substance that have similar effects.